Endocrine Abstracts

We present a case of a 48 year old male who presented originally with a 8mm prolactinoma. He presented with a reduced libido for 6 months, and lethargy and retro-orbital headaches for the previous 18–24 months. He had no visual disturbance. Initial investigations revealed hyperprolactinaemia with a level of over 4000 iu/L and a normal IGF1 of 184 iu/L in the presence of a pituitary macroadenoma (8 x 11mm). He responded well to Cabergoline with a noticeable improvement in ...

We present a case of a 73 year old female with recurrent non-functioning adenoma and co-existent mantle cell lymphoma within the pituitary fossa. Mantle cell lymphoma (MCL) is rare comprising around 6% of non-Hodgkin lymphoma diagnoses. It infrequently involves the central nervous system, with only one published case of involvement of the pituitary gland. Our patient initially presented in April 2003 with marked visual loss due to a large non-functioning cystic pituitary macro...

Background: Non-functioning pituitary adenomas (NFPAs) are the most common pituitary macroadenomas with a prevalence of 7-22 per 100,000 population. As they are non-secretory, they tend to present late with visual disturbances, headaches or hormonal deficiencies. Surgery is the main treatment for NFPAs, particularly endoscopic transsphenoidal surgery which can be associated with surgical and endocrine complications.Aims: To compare pre- and post-operativ...

Post-pituitary surgery hyponatraemia (HN, sodium <135 mmol/l) is relatively common and may result in prolonged hospitalisation. Herein we report a retrospective analysis of our experience in a tertiary institute. We conducted a retrospective case note review of 318 patients (M 54%, F 46%, mean age 58 years) 65.7% non-functioning adenoma (NFA), 10% somatotropinoma, 5% prolactinoma, 11% corticotropinoma (half were clinically silent), 8% craniopharyngioma, an...

Background: Craniopharyngioma (CP) is a rare sellar or suprasellar epithelial tumour with a prevalence of approximately 2 per million and it occurs either in childhood between the ages of 5 and 14 years or in adulthood between the ages of 50 and 74 years. Histologically, CPs are divided into adamantinomatous, more prevalent in children, and papillary, more prevalent in adults. They are usually benign, but rare cases of malignant CPs have been reported. Clinical presentation is...